(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

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Chemical Name:(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid
CAS No.:210777-21-2
Molecular Formula:C₄₃H₅₅N₅O₁₂
Molecular Weight:833.936
Hs Code.:

(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

Synonyms:(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

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Chemical Property of (S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

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Technology Process of (S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

There total 1 articles about (S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71764-12-0
(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionic acid pentafluorophenyl ester

: (S)-2-[2-((R)-2-Amino-5-benzyloxycarbonylamino-pentanoylamino)-acetylamino]-3-phenyl-propionic acid; compound with trifluoro-acetic acid

: 210777-21-2
(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; Yield given;
DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

: 210777-21-2
(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

: 210777-41-6
(S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium; In methanol; acetic acid; Yield given;
DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

: 210777-21-2
(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

: 210777-30-3
Carbonic acid 4-[(S)-2-((3S,6S,12R)-6-benzyl-3-isobutyl-2,5,8,11-tetraoxo-1,4,7,10-tetraaza-cyclopentadec-12-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd black / methanol; aq. acetic acid

2: DIEA / dimethylformamide

3: H₂ / Pd black / methanol; aq. acetic acid

4: DPPA, Et₃N / dimethylformamide / -20 °C

With diphenyl-phosphinic acid; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80060-3