Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Base Information

• Chemical Name: Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester
• CAS No.: 210777-29-0
• Molecular Formula: C₄₀H₅₄N₆O₁₀
• Molecular Weight: 778.903

Synonyms:Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Chemical Property of Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Chemical Property:

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Technology Process of Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

There total 4 articles about Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-5-[((S)-pyrrolidine-2-carbonyl)-amino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-42-7) → Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-29-0)

Guidance literature:

With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at -20 ℃; for 168h; Yield given;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

(S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-41-6) → Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1: DIEA / dimethylformamide

2: H₂ / Pd black / methanol; aq. acetic acid

3: DPPA, Et₃N / dimethylformamide / 168 h / -20 °C

With diphenyl-phosphinic acid; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

(S)-2-((R)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-4-{[((S)-1-carboxy-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester (210777-22-3) → Carbonic acid 4-[(S)-2-((5S,11R,16aS)-5-benzyl-4,7,10,16-tetraoxo-hexadecahydro-3a,6,9,15-tetraaza-cyclopentacyclopentadecen-11-ylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd black / methanol; aq. acetic acid

2: DPPA, Et₃N / dimethylformamide / 168 h / -20 °C

With diphenyl-phosphinic acid; hydrogen; triethylamine; palladium; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80060-3

upstream raw materials:

(S)-2-(2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-5-[((S)-pyrrolidine-2-carbonyl)-amino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

(S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

(S)-2-((R)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-4-{[((S)-1-carboxy-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester

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