dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate

Base Information

• Chemical Name: dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate
• CAS No.: 75453-28-0
• Molecular Formula: C₂₃H₁₅NO₇*2Na
• Molecular Weight: 463.354
• Mol file: 75453-28-0.mol

Synonyms:dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate

Chemical Property of dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate

There total 11 articles about dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

diethyl 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quilnoline-2,8-dicarboxylate (75453-27-9) → dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate (75453-28-0)

Guidance literature:

With sodium hydroxide; In methanol; for 0.25h; Heating;

DOI:10.1021/jm00150a014

Reference yield:

N-(4-acetyl-3-hydroxyphenyl)acetamide (40547-58-8) → dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate (75453-28-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 81 percent / potassium carbonate / dimethylformamide / 5 h

2: 70 percent / various solvent(s) / 4 h / Heating

3: 98 percent / H₂ / PtO₂ / acetic acid / 2206.5 Torr

4: 93 percent / aq. HCl / 100 °C / Heating

5: ethanol / 17 h / Heating

6: 74 percent / diphenyl ether / 0.08 h / Heating

7: 88 percent / POCl₃ / benzene / 25 h / Ambient temperature

8: 69 percent / potassium hydroxide / 1.5 h / 60 - 65 °C

9: 1.) EtONa, 2.) gas HCl / 1.) ethanol, a) RT, 1 h, b) reflux, 1.5 h, 2.) dioxane, 15 min

10: 54 percent / 0.1 M NaOH / methanol / 0.25 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; hydrogen; sodium ethanolate; potassium carbonate; trichlorophosphate; platinum(IV) oxide; In methanol; diphenylether; ethanol; acetic acid; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00150a014

Reference yield:

4-Acetamido-2-allyloxyacetophenone (7298-72-8) → dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate (75453-28-0)

Guidance literature:

Multi-step reaction with 9 steps

1: 70 percent / various solvent(s) / 4 h / Heating

2: 98 percent / H₂ / PtO₂ / acetic acid / 2206.5 Torr

3: 93 percent / aq. HCl / 100 °C / Heating

4: ethanol / 17 h / Heating

5: 74 percent / diphenyl ether / 0.08 h / Heating

6: 88 percent / POCl₃ / benzene / 25 h / Ambient temperature

7: 69 percent / potassium hydroxide / 1.5 h / 60 - 65 °C

8: 1.) EtONa, 2.) gas HCl / 1.) ethanol, a) RT, 1 h, b) reflux, 1.5 h, 2.) dioxane, 15 min

9: 54 percent / 0.1 M NaOH / methanol / 0.25 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; hydrogen; sodium ethanolate; trichlorophosphate; platinum(IV) oxide; In methanol; diphenylether; ethanol; acetic acid; benzene;

DOI:10.1021/jm00150a014

upstream raw materials:

diethyl 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quilnoline-2,8-dicarboxylate

N-(4-acetyl-3-hydroxyphenyl)acetamide

4-Acetamido-2-allyloxyacetophenone

methyl 6-acetyl-1,4-dihydro-7-hydroxy-4-oxo-8-propylquinoline-2-carboxylate