(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

Base Information

Chemical Name:(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate
CAS No.:1419013-60-7
Molecular Formula:C₁₄H₁₄Cl₃N₃O₄
Molecular Weight:394.642
Hs Code.:

Synonyms:(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

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Technology Process of (S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

There total 1 articles about (S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39910-24-2
ethyl-3-hydroxy-2-diazo-3-(4-methoxyphenyl)-propanoate

: 545-06-2
trichloroacetonitrile

: (R)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

: 1419013-60-7
(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

Guidance literature:: With sodium hydride; In hexane; at 0 - 4 ℃; for 18h; Overall yield = 77 %; Overall yield = 27 mg; enantioselective reaction;
DOI:10.1021/ol303011f

Reference yield:

: 1419013-60-7
(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

: C₁₄H₁₄Cl₃NO₅

Guidance literature:: With Oxone; sodium hydrogencarbonate; In dichloromethane; water; acetone; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol303011f

Reference yield:

: 1419013-60-7
(S)-ethyl 2-diazo-3-(4-methoxyphenyl)-3-(2,2,2-trichloroacetamido)propanoate

: 220736-25-4,259794-13-3
(+)-(4S,5S)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: Oxone; sodium hydrogencarbonate / dichloromethane; acetone; water / 1 h / 0 - 20 °C

2: sodium tetrahydroborate / dichloromethane / 3 h / -78 °C

3: sodium tetrahydroborate / methanol / 15 h / 20 °C

4: sodium methylate / methanol / 12 h / 20 °C

With Oxone; sodium tetrahydroborate; sodium methylate; sodium hydrogencarbonate; In methanol; dichloromethane; water; acetone;
DOI:10.1021/ol303011f