(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

Base Information

Chemical Name:(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one
CAS No.:151914-97-5
Molecular Formula:C₁₉H₃₇NO₂Si
Molecular Weight:339.594
Hs Code.:

Synonyms:(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

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Technology Process of (R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

There total 1 articles about (R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 4-Oxo-2-(2-oxo-pentyl)-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 65253-04-5
(-)-8-phenylmenthol

: 151914-97-5
(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: With sodium carbonate; potassium tri-sec-butyl-borohydride; Yield given. Multistep reaction; 1.) THF, -78 deg C, 2.) MeOH, reflux, 6 h;
DOI:10.1021/ja00072a053

Reference yield:

: 151914-97-5
(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

: 39027-77-5
(-)-porantheridine

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / TEA / tetrahydrofuran / Heating

2: 92 percent / 30percent HBr, AcOH / CH₂Cl₂ / 24 h / Ambient temperature

3: 81 percent / CuBr, BF₃*OEt₂ / tetrahydrofuran / -78 °C

4: 1.) LDA / 1.) THF

5: 1.) Li₂CO₃, H₂, 2.) KOH / 1.) 5percent Pd/C / 1.) EtOAc, 1 atm, 2.) EtOH, reflux, 2 d

6: 66 percent / TsOH, 4A molecular sieves / benzene / 6 h / Heating

With potassium hydroxide; 4 A molecular sieve; TEA; boron trifluoride diethyl etherate; hydrogen bromide; hydrogen; lithium carbonate; toluene-4-sulfonic acid; acetic acid; copper(I) bromide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ja00072a053

Reference yield:

: 151914-97-5
(R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one

: 152005-78-2
(R)-1-{(2S,6S)-6-[3-(2-Methyl-[1,3]dioxolan-2-yl)-propyl]-piperidin-2-yl}-pentan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / TEA / tetrahydrofuran / Heating

2: 92 percent / 30percent HBr, AcOH / CH₂Cl₂ / 24 h / Ambient temperature

3: 81 percent / CuBr, BF₃*OEt₂ / tetrahydrofuran / -78 °C

4: 1.) LDA / 1.) THF

5: 1.) Li₂CO₃, H₂, 2.) KOH / 1.) 5percent Pd/C / 1.) EtOAc, 1 atm, 2.) EtOH, reflux, 2 d

With potassium hydroxide; TEA; boron trifluoride diethyl etherate; hydrogen bromide; hydrogen; lithium carbonate; acetic acid; copper(I) bromide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00072a053