39027-77-5

Upstream product

• 75969-86-7 Benzoic acid (R)-1-{(2S,6S)-6-[4-(tert-butyl-dimethyl-silanyloxy)-pentyl]-piperidin-2-ylmethyl}-butyl ester 
• 1121-89-7 piperidine-2,6-dione 
• 34164-50-6 4-penten-1-ylmagnesium bromide 
• 74283-04-8 6-(pent-4-enyl)piperidin-2-one 
• 75969-87-8 Benzoic acid (R)-1-[(2S,6S)-6-(4-hydroxy-pentyl)-piperidin-2-ylmethyl]-butyl ester 
• 34418-91-2 2,3,4,5-tetrahydropyridine N-oxide 
• 67-56-1 methanol 
• 151914-97-5 (R)-2-((R)-2-Hydroxy-pentyl)-5-triisopropylsilanyl-2,3-dihydro-1H-pyridin-4-one 
• 151915-01-4 Trifluoro-methanesulfonic acid (3R,4aR,8R)-8-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-1-oxo-3-propyl-4,4a,5,8-tetrahydro-3H-pyrido[1,2-c][1,3]oxazin-6-yl ester 
• 62026-31-7 [3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-magnesium chloride 
• 251321-60-5 (2S,6S)-N-(benzyloxycarbonyl)-2-(hydroxymethyl)-6-[(2R)-2-(benzyloxy)pentyl]piperidine 

Relevant academic research and scientific papers

Novel synthesis method of natural product (-)-Porantheridine

The invention discloses a novel synthesis method of a natural product (-)-Porantheridine, a compound shown in a known formula 1 is taken as the starting material, and a target molecule is synthesizedthrough a series of reactions of MHorner-Wadsworth-Emmons reaction, N-Michael reaction, Pd (II) catalyzed Wacker oxidization reaction and cyclization under the protection of a tertiary butylcarbonyl.The design of the whole route is unique and novel, the reaction condition of the reaction process is mild, the speed is high, side effects are relatively few, the operation is convenient, the conventional chemical agent is used in the route, raw materials are cheap and easy to get, and the synthesis cost is greatly lowered.

STEREOSELEKTIVE SYNTHESE VON (+/-)-PORANTHERIDIN

The synthesis of Porantheridine is described.Keystep of this synthesis is the 1,3-dipolar addition of a nitron to an alkene.