1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1374338-85-8
Molecular Formula:C₂₉H₂₂ClF₆N₃O₃
Molecular Weight:609.955
Hs Code.:

Synonyms:1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

There total 10 articles about 1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374342-08-1
methyl 1-{6-[4-chloro-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1374338-85-8
1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: methyl 1-{6-[4-chloro-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.25h;

Reference yield:

: 1374342-07-0
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclohexanone

: 1374338-85-8
1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 15 h / 80 °C / Inert atmosphere

1.2: 0.25 h / 60 °C

2.1: dichloromethane; methanol; diethyl ether / 0.33 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.2: 0.25 h / 60 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tetrabutyl ammonium fluoride; sodium carbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;

Reference yield:

: 1374339-17-9
1-{6-[4-chloro-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

: 1374338-85-8
1-(6-{4'-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-4-chlorobiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; methanol; diethyl ether / 0.33 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.2: 0.25 h / 60 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;