{(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 153647-56-4
• Molecular Formula: C₄₀H₄₂N₄O₆
• Molecular Weight: 674.797
• Mol file: 153647-56-4.mol

Synonyms:{(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine, acid chloride (103321-59-1) + [(S)-2-(3,4-Dihydro-1H-phthalazin-2-yl)-1-methyl-2-oxo-ethyl]-carbamic acid benzyl ester (153647-49-5) → {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (153647-56-4)

Guidance literature:

With 2,6-di-tert-butyl-pyridine; In dichloromethane; for 0.0833333h;

DOI:10.1016/S0040-4039(00)61615-5

Reference yield:

N-Cbz-Ala (1142-20-7) → {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (153647-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h

2: 97 percent / 2,6-di-tert-butylpyridine / CH₂Cl₂ / 0.08 h

With 2,6-di-tert-butyl-pyridine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)61615-5

Reference yield:

1,2,3,4-tetrahydrophthalazine hydrochloride (60789-87-9) → {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-propionyl)-3,4-dihydro-1H-phthalazine-2-carbonyl]-3-methyl-butyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (153647-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h

2: 97 percent / 2,6-di-tert-butylpyridine / CH₂Cl₂ / 0.08 h

With 2,6-di-tert-butyl-pyridine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)61615-5

upstream raw materials:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine, acid chloride

[(S)-2-(3,4-Dihydro-1H-phthalazin-2-yl)-1-methyl-2-oxo-ethyl]-carbamic acid benzyl ester

N-Cbz-Ala

1,2,3,4-tetrahydrophthalazine hydrochloride

Downstream raw materials:

{(S)-2-[3-((S)-2-Amino-4-methyl-pentanoyl)-3,4-dihydro-1H-phthalazin-2-yl]-1-methyl-2-oxo-ethyl}-carbamic acid benzyl ester