4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Base Information

Chemical Name:4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol
CAS No.:1373491-51-0
Molecular Formula:C₁₇H₂₀ClNOS
Molecular Weight:321.871
Hs Code.:

Synonyms:4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

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Chemical Property of 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Chemical Property:

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Technology Process of 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

There total 5 articles about 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373491-72-5
4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butyric acid ethyl ester

: 1373491-51-0
4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Guidance literature:: 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butyric acid ethyl ester; With lithium aluminium tetrahydride; In diethyl ether; Inert atmosphere; Reflux;

With hydrogenchloride; In diethyl ether; water;

With sodium hydroxide; In water; pH=7;

Reference yield:

: 135046-48-9,120202-71-3,144077-07-6
clopidogrel bisulfate

: 1373491-51-0
4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water

1.2: Inert atmosphere; Reflux

1.3: pH 7

2.1: thionyl chloride / tetrahydrofuran / 20 °C

2.2: pH 7

3.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere

3.2: 2 h / Reflux

4.1: lithium chloride / water; dimethyl sulfoxide / 4 h / 190 °C

5.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

5.3: pH 7

With lithium aluminium tetrahydride; thionyl chloride; ethanol; sodium; sodium hydrogencarbonate; lithium chloride; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;

Reference yield:

: 1373491-50-9
2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanol

: 1373491-51-0
4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / tetrahydrofuran / 20 °C

1.2: pH 7

2.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / Reflux

3.1: lithium chloride / water; dimethyl sulfoxide / 4 h / 190 °C

4.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

4.3: pH 7

With lithium aluminium tetrahydride; thionyl chloride; ethanol; sodium; lithium chloride; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;