Clopidogrel hydrogen sulfate

Base Information

• Chemical Name: Clopidogrel hydrogen sulfate
• CAS No.: 135046-48-9
• Molecular Formula: C16H18ClNO6S2
• Molecular Weight: 419.907
• Hs Code.: 2934999090
• Mol file: 135046-48-9.mol

Synonyms:Clopidogrel Hydrogen sulfate￡¨I￡?;Clopidogrel Bisulphate;Clopidogrel hydrogen sulfate;Clopidogrel;Clopidogrelhydrogensulfate;

Chemical Property of Clopidogrel hydrogen sulfate

Chemical Property:

• Appearance/Colour: colorless to light yellow liquid
• Vapor Pressure: 8.71E-09mmHg at 25°C
• Melting Point: 184 °C
• Boiling Point: 423.7 °C at 760 mmHg
• Flash Point: 210 °C
• PSA: 140.76000
• LogP: 4.03980
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ~26mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

rac-Clopidogrel Hydrogen Sulfate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as an antithrombotic platelet aggregation inhibitors rac-Clopidogrel Hydrogen Sulfate is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.

Technology Process of Clopidogrel hydrogen sulfate

There total 7 articles about Clopidogrel hydrogen sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

clopidogrel (90055-48-4,94188-84-8) → clopidogrel bisulfate (135046-48-9,120202-71-3,144077-07-6)

Guidance literature:

With sulfuric acid; In water; acetone; at 20 ℃; for 2h;

Reference yield: 90.0%

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride (28783-41-7) + methyl 2-bromo-2-(2-chlorophenyl)acetate (85259-19-4,622835-93-2,66504-71-0) → clopidogrel bisulfate (135046-48-9,120202-71-3,144077-07-6)

Guidance literature:

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride; With sodium carbonate; In water; at 25 ℃; for 0.5h;

methyl 2-bromo-2-(2-chlorophenyl)acetate; In water; toluene; at 20 ℃; for 12h;

With sulfuric acid; In ethyl acetate; for 1h; Reagent/catalyst; Solvent;

DOI:10.1080/15533174.2015.1137028

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 2-bromo-2-(2-chlorophenyl)acetate (85259-19-4,622835-93-2,66504-71-0) → clopidogrel bisulfate (135046-48-9,120202-71-3,144077-07-6)

Guidance literature:

[2-(2-thyenyl)ethyl]amine; formaldehyd; In 1,2-dichloro-ethane; for 4h; Heating / reflux;

With hydrogenchloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 30 - 70 ℃; for 4h;

methyl 2-bromo-2-(2-chlorophenyl)acetate; With sulfuric acid; sodium carbonate; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

methyl 2-bromo-2-(2-chlorophenyl)acetate

clopidogrel

formaldehyd

Downstream raw materials:

clopidogrel

(E)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetaldehyde O-methyl oxime

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethyl acetate

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetaldehyde

Refernces

• 1、 -. "RACEMIZATION PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF CLOPIDOGREL HYDROGEN SULPHATE". Page/Page column 13. . Retrieved 2009/07/18.
• 2、 -. "Preparation of Clopidogrel and Its Analogues Methyl Tetrahydrothienopyridine Acetate Compuunds". Page/Page column 11. . Retrieved 2008/12/08.