N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

Base Information

• Chemical Name: N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide
• CAS No.: 1460301-61-4
• Molecular Formula: C₄₄H₄₄N₄O₅
• Molecular Weight: 708.857

Synonyms:N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

Chemical Property of N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

There total 15 articles about N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-[(10S,12S,16S)-16-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.010'14]hexacosa-1(26),2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide (1460301-55-6) + phenylacetyl chloride (103-80-0) → N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.010'14]hexacosa-1(26),2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide (1460301-61-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride (1460301-53-4) → N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.010'14]hexacosa-1(26),2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide (1460301-61-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 4 h / 0 °C

2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 4 h / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 3 h / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; 10 wt% Pd(OH)2 on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

benzyl N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate (1460301-54-5) → N-[(10S,12S,16S)-20-methyl-15,21-dioxo-16-[(2-phenylacetyl)amino]-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.010'14]hexacosa-1(26),2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide (1460301-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 4 h / 20 °C / 760.05 Torr

2: pyridine / dichloromethane / 3 h / 0 °C

With pyridine; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; dichloromethane;

upstream raw materials:

benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

benzyl N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate

N-[(10S,12S,16S)-16-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

phenylacetyl chloride

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