3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

Base Information

Chemical Name:3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile
CAS No.:1449506-70-0
Molecular Formula:C₂₄H₂₆N₆O
Molecular Weight:414.51
Hs Code.:

Synonyms:3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

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Chemical Property of 3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

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Technology Process of 3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

There total 10 articles about 3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449506-70-0
3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

5.2: 0.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1449506-75-5
N-(2-ethyl-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridine-amine

: 372-09-8
cyanoacetic acid

: 1449506-70-0
3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 8h;

Reference yield:

: 1449506-72-2
tert-butyl 4-(4-amino-3-ethylphenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1449506-70-0
3-(4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridin-1(2H)-yl)-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;