Technology Process of 2-(3-fluorophenyl)-4,7-dimethoxybenzo[b]furan
There total 3 articles about 2-(3-fluorophenyl)-4,7-dimethoxybenzo[b]furan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; water;
at 150 ℃;
for 0.2h;
Inert atmosphere;
Sealed tube;
Microwave irradiation;
DOI:10.3762/bjoc.7.146
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium di-tert-butyl(2,2,6,6-tetramethylpiperidino)zincate / tetrahydrofuran / -78 - -30 °C
1.2: -30 - 20 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / 2.5 h / 75 °C / Inert atmosphere; neat (no solvent)
3.1: tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos / 1,4-dioxane; water / 0.2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); lithium di-tert-butyl(2,2,6,6-tetramethylpiperidino)zincate; tetrabutyl ammonium fluoride; potassium hydroxide; tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; water;
2.1: Sonogashira coupling;
DOI:10.3762/bjoc.7.146
- Guidance literature:
-
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / 2.5 h / 75 °C / Inert atmosphere; neat (no solvent)
2: tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos / 1,4-dioxane; water / 0.2 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation
With
bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; water;
1: Sonogashira coupling;
DOI:10.3762/bjoc.7.146
