Technology Process of 2-BroMo-3-iodo-1,4-diMethoxybenzene, 97%
There total 4 articles about 2-BroMo-3-iodo-1,4-diMethoxybenzene, 97% which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-2,5-dimethoxybenzene;
With
lithium di-tert-butyl(2,2,6,6-tetramethylpiperidino)zincate;
In
tetrahydrofuran;
at -78 - -30 ℃;
With
iodine;
In
tetrahydrofuran;
at -30 - 20 ℃;
DOI:10.3762/bjoc.7.146
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) sodium nitrite, conc. H2SO4, 2.) copper(I)bromide, hydrogen bromide / 1.) methanol, water, 0 deg C, 30 min, 2.) methanol, water, reflux, 1 h
2: 100 percent / activated carbon, ferric chloride hexahydrate, hydrazine hydrate / methanol / 12 h / Heating
3: 1.) sodium nitrite, conc. HCl, 2.) potassium iodide / 1.) water, 0 deg C, 20 min, 2.) water, RT, overnight
With
hydrogenchloride; sulfuric acid; hydrogen bromide; iron(III) chloride; pyrographite; hydrazine hydrate; potassium iodide; copper(I) bromide; sodium nitrite;
In
methanol;
DOI:10.1021/jo00383a032
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / activated carbon, ferric chloride hexahydrate, hydrazine hydrate / methanol / 12 h / Heating
2: 1.) sodium nitrite, conc. HCl, 2.) potassium iodide / 1.) water, 0 deg C, 20 min, 2.) water, RT, overnight
With
hydrogenchloride; iron(III) chloride; pyrographite; hydrazine hydrate; potassium iodide; sodium nitrite;
In
methanol;
DOI:10.1021/jo00383a032
