N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide

Base Information

• Chemical Name: N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide
• CAS No.: 898261-58-0
• Molecular Formula: C₂₀H₂₈N₄O₅
• Molecular Weight: 404.466
• Mol file: 898261-58-0.mol

Synonyms:N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide

Chemical Property of N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide

There total 1 articles about N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

Cyclohexyl isocyanide (931-53-3) + p-methoxybenzoylformic acid (7099-91-4) + acetone semicarbazone (110-20-3) → N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide (898261-58-0)

Guidance literature:

In methanol; at 20 ℃; for 72h;

DOI:10.1021/jo060434y

Reference yield: 54.0%

N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide (898261-58-0) → N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide (898261-67-1)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 12h;

DOI:10.1021/jo060434y

Reference yield:

N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide (898261-58-0) → N-cyclohexyl-2-[3-methoxy-5-(4-methoxyphenyl)-6-oxo-6H-[1,2,4]triazin-1-yl]isobutyramide

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / sodium ethoxide / ethanol / 12 h / 20 °C

2: 83 percent / diethyl ether; CHCl₃ / 12 h / 20 °C

With sodium ethanolate; In diethyl ether; ethanol; chloroform;

DOI:10.1021/jo060434y

upstream raw materials:

Cyclohexyl isocyanide

p-methoxybenzoylformic acid

acetone semicarbazone

Downstream raw materials:

N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide