N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

Base Information

Chemical Name:N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide
CAS No.:898261-67-1
Molecular Formula:C₂₀H₂₆N₄O₄
Molecular Weight:386.451
Hs Code.:

Synonyms:N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

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Chemical Property of N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

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Technology Process of N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

There total 3 articles about N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 898261-58-0
N-cyclohexyl-2-[N'-carbamoyl-N-(2-oxo-2-{p-methoxy}phenylacetyl)hydrazino]isobutyramide

: 898261-67-1
N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 12h;
DOI:10.1021/jo060434y

Reference yield:

: 931-53-3
Cyclohexyl isocyanide

: 898261-67-1
N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / methanol / 72 h / 20 °C

2: 54 percent / sodium ethoxide / ethanol / 12 h / 20 °C

With sodium ethanolate; In methanol; ethanol; 1: Ugi reaction;
DOI:10.1021/jo060434y

Reference yield:

: 7099-91-4
p-methoxybenzoylformic acid

: 898261-67-1
N-cyclohexyl-2-(3-hydroxy-6-oxo-5-(p-methoxyphenyl)-6H-[1,2,4]triazin-1-yl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / methanol / 72 h / 20 °C

2: 54 percent / sodium ethoxide / ethanol / 12 h / 20 °C

With sodium ethanolate; In methanol; ethanol; 1: Ugi reaction;
DOI:10.1021/jo060434y