2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Base Information

Chemical Name:2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate
CAS No.:1456906-94-7
Molecular Formula:C₂HF₃O₂*C₃₀H₃₅N₃O₂
Molecular Weight:583.651
Hs Code.:

Synonyms:2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

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Chemical Property of 2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

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Technology Process of 2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

There total 8 articles about 2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 2-amino-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide dihydrochloride

: 99-94-5
p-Toluic acid

: 76-05-1
trifluoroacetic acid

: 1456906-94-7
2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: 2-amino-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide dihydrochloride; p-Toluic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

trifluoroacetic acid; In water;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456906-94-7
2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 13.5 h / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 1.5 h / -20 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

6: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

7: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999

Reference yield:

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: 1456906-94-7
2-[N-(4-methylbenzenecarbonylamino)]-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 21.5 h / 40 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 0 - 20 °C

3: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201303999