2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

Base Information

Chemical Name:2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide
CAS No.:1456905-64-8
Molecular Formula:C₁₉H₃₀N₂O₆S
Molecular Weight:414.523
Hs Code.:

Synonyms:2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

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Chemical Property of 2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

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Technology Process of 2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

There total 5 articles about 2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1456905-62-6
2-(N-tert-butoxycarbonylamino)-6-hydroxy-N-benzylhexanamide

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at -20 - 20 ℃; for 1.5h;

Reference yield: 82.0%

: 1456905-62-6
2-(N-tert-butoxycarbonylamino)-6-hydroxy-N-benzylhexanamide

: 124-63-0
methanesulfonyl chloride

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at -20 - 20 ℃; for 1.5h;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456905-64-8
2-(N-tert-butoxycarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 13.5 h / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 1.5 h / -20 - 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999