2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1189050-55-2
• Molecular Formula: C₁₆H₁₅BrN₂O₂
• Molecular Weight: 347.211
• Mol file: 1189050-55-2.mol

Synonyms:2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(p-bromophenyl)tetrahydroisoquinoline + nitromethane (75-52-5) → 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline (1189050-55-2)

Guidance literature:

With eosin Y and 1,3,5-triethynylbenzene based porous organic polymer; at 20 ℃; for 20h; Sealed tube; Irradiation;

DOI:10.1039/c6ra25123d

Reference yield: 86.0%

→ 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline (1189050-55-2)

Guidance literature:

With UIO-68Se; air; at 20 ℃; Irradiation;

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → 2-(4-bromophenyl)-1-(nitromethyl)-1,2,3,4-tetrahydroisoquinoline (1189050-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 20 - 90 °C / Inert atmosphere

2: eosin / 10 h / 20 °C / Irradiation

With potassium phosphate; copper(l) iodide; eosin; In ethylene glycol; isopropyl alcohol;

DOI:10.1021/ol201376v

upstream raw materials:

nitromethane

1,2,3,4-tetrahydroisoquinoline

1,4-bromoiodobenzene

2-(trimethylsilyl)phenyl trifluoromethanesulfonate