6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

Base Information

Chemical Name:6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol
CAS No.:113748-84-8
Molecular Formula:C₃₀H₁₉F₇O₂
Molecular Weight:544.468
Hs Code.:

Synonyms:6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

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Chemical Property of 6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

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Technology Process of 6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

There total 5 articles about 6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 113748-82-6
3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-84-8
6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: With hydrogen bromide; acetic acid; In water; for 10h; Inert atmosphere; Reflux;
DOI:10.1021/jm500569h

Reference yield:

: 28557-00-8
phenylzinc chloride

: 113748-84-8
6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 83 percent / HBr / acetic acid / 5 h / Heating

With hydrogen bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-80-4
3-methoxy-6,7-dihydro-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-84-8
6,7-dihydro-8-phenyl-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocyclohepten-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 3 h

2: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

3: 83 percent / HBr / acetic acid / 5 h / Heating

With hydrogen bromide; pyridinium hydrobromide perbromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005