(Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester

Base Information

• Chemical Name: (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester
• CAS No.: 1242683-14-2
• Molecular Formula: C₁₂H₁₂BrNO₃
• Molecular Weight: 298.136
• Mol file: 1242683-14-2.mol

Synonyms:(Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester

Chemical Property of (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester

There total 1 articles about (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-α-N-benzoylamino-2-butenoic acid methylester (60027-58-9) → (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester (1242683-14-2) + (E)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester (99990-33-7)

Guidance literature:

(Z)-α-N-benzoylamino-2-butenoic acid methylester; With N-Bromosuccinimide; In dichloromethane; for 16h;

With triethylamine; In dichloromethane; for 1h;

DOI:10.1007/s00726-009-0466-x

Reference yield: 89.0%

(Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester (1242683-14-2) → methyl 5-methyl-2-phenyloxazole-4-carboxylate (100063-41-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2010.09.014

Reference yield: 37.0%

(Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester (1242683-14-2) + benzamide (55-21-0,27208-38-4) → methyl 5-methyl-2-phenyloxazole-4-carboxylate (100063-41-0) + methyl 2-benzoylamino-3-methylacrylate (105909-91-9)

Guidance literature:

With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 110 ℃; for 5h; Schlenk technique; Sealed tube;

DOI:10.1007/s00726-012-1337-4

upstream raw materials:

(Z)-α-N-benzoylamino-2-butenoic acid methylester

Downstream raw materials:

methyl 5-methyl-2-phenyloxazole-4-carboxylate

methyl 2-benzoylamino-3-methylacrylate