105909-91-9Relevant articles and documents
Preparation method of chiral alpha-amino acid
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Paragraph 0057; 0058; 0059, (2016/10/08)
The invention discloses a preparation method of chiral alpha-amino acid. Initial raw materials comprising aldehyde and N-acryl substituted glycine undergo Erlenmeyer-Plochl cyclization, hydrolysis or alcoholysis, asymmetric catalytic hydrogenation and acid hydrolysis to obtain the chiral alpha-amino acid compound. The method adopting the above synthesis route has the advantages of mild reaction conditions, simple technological operation, safe and stable production, realization of high yield, good chemical purity and good optical purity of the above obtained product, wide application range, and suitableness for industrial production.
A mild high yielding synthesis of oxazole-4-carboxylate derivatives
Ferreira, Paula M.T.,Castanheira, Elisabete M.S.,Monteiro, Luís S.,Pereira, Goreti,Vilaa, Helena
scheme or table, p. 8672 - 8680 (2011/01/04)
Several 2,5-disubstituted oxazole-4-carboxylates were prepared in high yields from the methyl esters of N-acyl-β-halodehydroaminobutyric acid derivatives by treatment with a 2% solution of DBU in acetonitrile. The scope of this reaction was investigated a
