(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

Base Information

Chemical Name:(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate
CAS No.:886447-56-9
Molecular Formula:C₃₄H₃₉N₅O₆
Molecular Weight:613.714
Hs Code.:

Synonyms:(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

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Chemical Property of (+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

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Technology Process of (+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

There total 4 articles about (+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: [4-(2,3-dihydro-1H-isoindole-1-carbonyl)-piperazin-1-yl]-acetic acid ethyl ester

: 181519-21-1
3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetic acid

: 886447-56-9
(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2005.11.058

Reference yield:

: 204320-59-2
(+/-)-2-(9-fluorenylmethoxycarbonyl)-1-isoindolinecarboxylic acid

: 886447-56-9
(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl salt; HOBt; Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: TBAF / dimethylformamide; tetrahydrofuran / 1 h / 20 °C

3: 84 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl salt; HOBt; Et₃N / dimethylformamide; tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.058

Reference yield:

: (+/-)-ethyl [4-[2-(9-fluorenylmethoxycarbonyl)-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

: 886447-56-9
(+/-)-ethyl [4-[2-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-1-isoindolinylcarbonyl]-1-piperazinyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / dimethylformamide; tetrahydrofuran / 1 h / 20 °C

2: 84 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl salt; HOBt; Et₃N / dimethylformamide; tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.058