Technology Process of 6-amino-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
There total 10 articles about 6-amino-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl acetamide / 12 h / 0 - 20 °C
2: potassium hydroxide; pyridine / 2 h / 60 °C
3: acetic acid; sulfuric acid / 1 h / Reflux
4: trimethylsilylazide; copper; ethanolamine / N,N-dimethyl acetamide / 4 h / 120 °C / Sealed tube
5: hydrogen bromide / 12 h / Reflux
With
pyridine; trimethylsilylazide; sulfuric acid; hydrogen bromide; copper; ethanolamine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide;
In
dichloromethane; N,N-dimethyl acetamide;
2: |Baker-Venkataraman Rearrangement;
DOI:10.1016/j.tet.2014.04.022
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid; sulfuric acid / 1 h / Reflux
2: trimethylsilylazide; copper; ethanolamine / N,N-dimethyl acetamide / 4 h / 120 °C / Sealed tube
3: hydrogen bromide / 12 h / Reflux
With
trimethylsilylazide; sulfuric acid; hydrogen bromide; copper; ethanolamine; acetic acid;
In
N,N-dimethyl acetamide;
DOI:10.1016/j.tet.2014.04.022
