36768-27-1

Upstream product

• 22362-66-9 3,5-dibromo-2-hydroxyacetophenone 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 54197-78-3 6-bromo-2-(3,4-dimethoxyphenyl)-4H-chromen-4-one 
• 101576-11-8 6,8-dibromo-2-(3,4-dimethoxyphenyl)-4H-chromen-4-one 
• 1609456-08-7 5'-bromo-2'-(3,4-dimethoxybenzoyloxy)acetophenone 
• 93-07-2 Veratric acid 

Downstream Products

• 1609456-15-6 6-amino-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES

This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Copper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids

Aminoflavonoids are unique antioxidants comparing to other abundant flavonoids in nature. Their syntheses and biological activities were scarcely reported. An effectively copper-mediated amination of the corresponding bromoflavonoids to synthesize a serie