Technology Process of 1-benzoxy-(4S,8S,12S,16S,20S)-4,8,12,16,20-pentamethylpentacosane
There total 22 articles about 1-benzoxy-(4S,8S,12S,16S,20S)-4,8,12,16,20-pentamethylpentacosane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran; diethyl ether;
at -78 - 0 ℃;
Inert atmosphere;
DOI:10.1021/jo4006602
- Guidance literature:
-
Multi-step reaction with 15 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 20 °C / Inert atmosphere
3.1: sodium peroxoborate tetrahydrate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
8.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
10.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
11.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
12.1: hydrazine; copper(II) sulfate; oxygen / ethanol / 15 h / 70 °C
13.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
14.1: dmap / pyridine / 0 - 20 °C / Inert atmosphere
15.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
With
dmap; copper(I) bromide dimethylsulfide complex; sodium peroxoborate tetrahydrate; tetrabutyl ammonium fluoride; oxygen; sodium hydride; Dess-Martin periodane; copper(II) sulfate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane; hydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; water;
1.1: |Julia-Kocienski Olefination / 8.1: |Julia-Kocienski Olefination / 11.1: |Julia-Kocienski Olefination;
DOI:10.1021/jo4006602
- Guidance literature:
-
Multi-step reaction with 10 steps
1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C
2: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere
3: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
5: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
6: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
7: hydrazine; copper(II) sulfate; oxygen / ethanol / 15 h / 70 °C
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
9: dmap / pyridine / 0 - 20 °C / Inert atmosphere
10: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / -78 - 0 °C / Inert atmosphere
With
dmap; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; oxygen; Dess-Martin periodane; copper(II) sulfate; lithium hexamethyldisilazane; hydrazine;
In
tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; ethyl acetate;
3: |Julia-Kocienski Olefination / 6: |Julia-Kocienski Olefination;
DOI:10.1021/jo4006602
