2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

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Chemical Name:2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine
CAS No.:1323917-69-6
Molecular Formula:C₂₈H₂₄FN₇
Molecular Weight:477.544
Hs Code.:

Synonyms:2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

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Chemical Property of 2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

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Technology Process of 2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

There total 5 articles about 2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1323920-03-1
C₃₂H₃₀FN₇O₂

: 1323917-69-6
2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

Guidance literature:: With formic acid; at 80 ℃;

Reference yield:

: 221050-88-0
4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1323917-69-6
2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1-methyl-pyrrolidin-2-one; water / 80 °C

2: formic acid / 80 °C

With formic acid; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; water; toluene;

Reference yield:

: 1323919-69-2
4-(5-bromo-pyridin-3-yl)-2-(2-fluoro-phenyl)-[1,8]naphthyridine

: 1323917-69-6
2-(2-fluoro-phenyl)-4-{5-[4-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-pyridin-3-yl}-[1,8]naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 80 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1-methyl-pyrrolidin-2-one; water / 80 °C

3: formic acid / 80 °C

With formic acid; potassium acetate; sodium carbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; toluene;