1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea
CAS No.:1400215-54-4
Molecular Formula:C₂₃H₂₀F₃N₇O
Molecular Weight:467.453
Hs Code.:

Synonyms:1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

There total 7 articles about 1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400221-02-4
4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)pyrimidin-2-amine

: 1400220-57-6
1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(4-trifluoromethylphenyl)-urea

: 1400215-54-4
1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: With potassium carbonate; palladium diacetate; tricyclohexylphosphine; In water; at 120 ℃; for 12h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 496863-48-0
1-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone

: 1400215-54-4
1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2 h / 80 °C

1.2: 80 °C

2.1: sodium hydroxide / tetrabutylammomium bromide / dichloromethane; water / 22 h

3.1: N-Bromosuccinimide / tetrahydrofuran / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.1: ammonium hydroxide / 1,4-dioxane / 1 h / 80 °C / Microwave irradiation

6.1: potassium carbonate / tricyclohexylphosphine; palladium diacetate / water / 12 h / 120 °C / Inert atmosphere; Microwave irradiation

With ammonium hydroxide; N-Bromosuccinimide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; tetrabutylammomium bromide; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1400221-04-6
4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidine

: 1400215-54-4
1-(3-(3-(2-aminopyrimidin-4-yl)-1-ethyl-1H-pyrazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / 1,4-dioxane / 1 h / 80 °C / Microwave irradiation

2: potassium carbonate / tricyclohexylphosphine; palladium diacetate / water / 12 h / 120 °C / Inert atmosphere; Microwave irradiation

With ammonium hydroxide; potassium carbonate; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; water;