4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Base Information

Chemical Name:4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline
CAS No.:1376711-47-5
Molecular Formula:C₂₈H₂₄N₂OS₂
Molecular Weight:468.643
Hs Code.:

Synonyms:4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Suppliers and Price of 4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

There total 5 articles about 4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 106-38-7
para-bromotoluene

: 1376711-46-4
4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)aniline

: 1376711-47-5
4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Guidance literature:: With tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 90 ℃; for 48h;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 1376711-44-2
5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol

: 1376711-47-5
4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: hydrazine hydrate / methanol; water / 50 °C

3.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

With tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; toluene; 1.2: Williamson-type etherification / 3.1: Hartwige-Buchwald coupling;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 20300-02-1
thiophene-2-carbothioamide

: 1376711-47-5
4-(4-methoxy-2-(thiophen-2-yl)thiazol-5-yl)-N,N-dip-tolylaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 24 h / Reflux

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

2.2: 24 h / 20 °C

3.1: hydrazine hydrate / methanol; water / 50 °C

4.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

With tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; water; dimethyl sulfoxide; toluene; 1.1: Hantzsch cyclization / 2.2: Williamson-type etherification / 4.1: Hartwige-Buchwald coupling;
DOI:10.1016/j.dyepig.2012.02.014