2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

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Chemical Name:2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid
CAS No.:1376711-55-5
Molecular Formula:C₃₆H₂₇N₃O₃S₃
Molecular Weight:645.827
Hs Code.:

Synonyms:2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

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Chemical Property of 2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

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Technology Process of 2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

There total 8 articles about 2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1376711-52-2
5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophene-5-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1376711-55-5
2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

Guidance literature:: With piperidine; In acetonitrile; for 4h; Reflux; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 20300-02-1
thiophene-2-carbothioamide

: 1376711-55-5
2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 24 h / Reflux

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

2.2: 24 h / 20 °C

3.1: hydrazine hydrate / methanol; water / 50 °C

4.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 24.5 h / -78 - 20 °C

5.3: 16 h / 95 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

6.2: 1.5 h / -78 - 20 °C

7.1: piperidine / acetonitrile / 4 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; dimethyl sulfoxide; toluene; acetonitrile; 1.1: Hantzsch cyclization / 2.2: Williamson-type etherification / 4.1: Hartwige-Buchwald coupling / 5.3: Stille coupling / 7.1: Knoevenagel condensation;
DOI:10.1016/j.dyepig.2012.02.014

Reference yield:

: 1376711-44-2
5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol

: 1376711-55-5
2-cyano-3-(5'-(5-(4-(di-p-tolylamino)phenyl)-4-methoxythiazol-2-yl)-2,2'-bithiophen-5-yl)acrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: hydrazine hydrate / methanol; water / 50 °C

3.1: tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 48 h / 90 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

4.2: 24.5 h / -78 - 20 °C

4.3: 16 h / 95 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 1.5 h / -78 - 20 °C

6.1: piperidine / acetonitrile / 4 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; tri-tert-butyl phosphine; potassium tert-butylate; hydrazine hydrate; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; dimethyl sulfoxide; toluene; acetonitrile; 1.2: Williamson-type etherification / 3.1: Hartwige-Buchwald coupling / 4.3: Stille coupling / 6.1: Knoevenagel condensation;
DOI:10.1016/j.dyepig.2012.02.014