5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

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Chemical Name:5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione
CAS No.:1268259-50-2
Molecular Formula:C₃₅H₄₈N₂O₉S
Molecular Weight:672.84
Hs Code.:

Synonyms:5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

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Chemical Property of 5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

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Technology Process of 5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

There total 4 articles about 5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.8%

: 1268259-49-9
5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethylene)thiazolidine-2,4-dione

: 1268259-50-2
5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

Guidance literature:: 5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethylene)thiazolidine-2,4-dione; With magnesium; In methanol; at 45 ℃; for 8h;

With di-tert-butyl dicarbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1002/cjoc.201090370

Reference yield:

: 79907-49-6
2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-ol

: 1268259-50-2
5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: piperidine; benzoic acid / toluene / 4 h / Reflux

3.1: magnesium / methanol / 8 h / 45 °C

3.2: 2 h / 20 °C

With piperidine; potassium tert-butylate; magnesium; benzoic acid; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cjoc.201090370

Reference yield:

: 56305-04-5,53188-07-1
trolox

: 1268259-50-2
5-(4-(6-(2-(2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy)ethoxy)-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenylmethyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 15 h / 20 °C

3.1: piperidine; benzoic acid / toluene / 4 h / Reflux

4.1: magnesium / methanol / 8 h / 45 °C

4.2: 2 h / 20 °C

With piperidine; lithium aluminium tetrahydride; potassium tert-butylate; magnesium; benzoic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cjoc.201090370