cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

Base Information

Chemical Name:cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione
CAS No.:112616-60-1
Molecular Formula:C₂₅H₁₉N₃O₂
Molecular Weight:393.445
Hs Code.:

Synonyms:cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

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Chemical Property of cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

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Technology Process of cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

There total 5 articles about cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 112616-46-3
4-{[(E)-2-(1-Benzyl-2,5-dioxo-pyrrolidin-3-yl)-phenylimino]-methyl}-benzonitrile

: 112616-60-1
cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; toluene; tert-butyl alcohol; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)90054-7

Reference yield:

: 58594-50-6
3-(2'-nitrophenyl)pyrrolidine-2,5-dione

: 112616-60-1
cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃ / acetone

2: 97 percent / H₂ / 10percent palladium on charcoal / toluene; ethanol / 18 h / 760 Torr

4: 47 percent / NaOtBu / 2-methyl-propan-2-ol; toluene; tetrahydrofuran / 0.25 h / 0 °C

With hydrogen; potassium carbonate; sodium t-butanolate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90054-7

Reference yield:

: 100-39-0
benzyl bromide

: 112616-60-1
cis-2(4-cyano)phenyl-2,3-dihydroindole-3-spiro-3'(N'benzyl)pyrrolidine-2',5'-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃ / acetone

2: 97 percent / H₂ / 10percent palladium on charcoal / toluene; ethanol / 18 h / 760 Torr

4: 47 percent / NaOtBu / 2-methyl-propan-2-ol; toluene; tetrahydrofuran / 0.25 h / 0 °C

With hydrogen; potassium carbonate; sodium t-butanolate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90054-7