{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

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Chemical Name:{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester
CAS No.:849411-97-8
Molecular Formula:C₃₈H₅₅O₈PSi
Molecular Weight:698.909
Hs Code.:

Synonyms:{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

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Chemical Property of {3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

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Technology Process of {3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

There total 11 articles about {3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 724422-95-1
dimethyl 3-{(1S)-1-[(1S)-1-benzyloxy-2-methoxymethoxyethyl]-6-(tert-butyldiphenylsilanyloxy)-1,5-dimethylhexyloxy}-2-oxopropylphosphonate

: 849411-97-8
{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at -40 ℃;
DOI:10.1021/ol049433n

Reference yield:

: 1575-74-2
(+-)-2-methyl-pent-4-enoic acid

: 849411-97-8
{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: LiAlH₄ / tetrahydrofuran / 16 h / 20 °C

2.1: 91 percent / imidazole / dimethylformamide / 12 h / 20 °C

3.1: 9-BBN dimer / tetrahydrofuran / 2 h / 0 °C

3.2: 74 percent / K₃PO₄ / Pd(PPh₃)4 / tetrahydrofuran; dioxane / 5 h / 85 °C

4.1: AD-mix-β; MeSO2NH2 / H2O; 2-methyl-propan-2-ol; toluene / 30 h / 0 °C

5.1: 74 percent / n-Bu₄NI; Ag₂O / CH₂Cl₂ / 5 h / 20 °C

6.1: LiAlH₄ / diethyl ether / 0 - 20 °C

7.1: 0.445 g / NaH / tetrahydrofuran / 3 h / 0 - 20 °C

8.1: [Rh(OAc)2]2 / toluene / 2 h / 110 °C

9.1: 118 mg / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

10.1: 84 percent / Me₃SiBr / CH₂Cl₂ / 0.5 h / -40 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; trimethylsilyl bromide; methanesulfonamide; AD-mix-β; tetra-(n-butyl)ammonium iodide; sodium hydride; silver(l) oxide; dimeric 9-borabicyclo[3.3.1]nonane; dirhodium tetraacetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3.2: Suzuki-Miyaura coupling / 4.1: Sharpless dihydroxylation;
DOI:10.1021/jo048115z

Reference yield:

: 5673-98-3
2-methylpent-4-en-1-ol

: 849411-97-8
{3-[(S)-1-((R)-1-Benzyloxy-2-hydroxy-ethyl)-6-(tert-butyl-diphenyl-silanyloxy)-1,5-dimethyl-hexyloxy]-2-oxo-propyl}-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 91 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: 9-BBN dimer / tetrahydrofuran / 2 h / 0 °C

2.2: 74 percent / K₃PO₄ / Pd(PPh₃)4 / tetrahydrofuran; dioxane / 5 h / 85 °C

3.1: AD-mix-β; MeSO2NH2 / H2O; 2-methyl-propan-2-ol; toluene / 30 h / 0 °C

4.1: 74 percent / n-Bu₄NI; Ag₂O / CH₂Cl₂ / 5 h / 20 °C

5.1: LiAlH₄ / diethyl ether / 0 - 20 °C

6.1: 0.445 g / NaH / tetrahydrofuran / 3 h / 0 - 20 °C

7.1: [Rh(OAc)2]2 / toluene / 2 h / 110 °C

8.1: 118 mg / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

9.1: 84 percent / Me₃SiBr / CH₂Cl₂ / 0.5 h / -40 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; trimethylsilyl bromide; methanesulfonamide; AD-mix-β; tetra-(n-butyl)ammonium iodide; sodium hydride; silver(l) oxide; dimeric 9-borabicyclo[3.3.1]nonane; dirhodium tetraacetate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 2.2: Suzuki-Miyaura coupling / 3.1: Sharpless dihydroxylation;
DOI:10.1021/jo048115z