3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid
• CAS No.: 431048-92-9
• Molecular Formula: C₃₄H₄₄N₂O₇Si
• Molecular Weight: 620.818
• Mol file: 431048-92-9.mol

Synonyms:3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid

Chemical Property of 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid

There total 9 articles about 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl 2-(2-formyl-6-methoxy-3-pyridyl)-5-((1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropyl)carbamoyl)benzoate → 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid (431048-92-9)

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2013.06.028

Reference yield:

6-methoxypyridine-2-carbaldehyde (54221-96-4) → 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid (431048-92-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N',N'-trimethylenediamine; n-butyllithium / tetrahydrofuran; hexane; cyclohexane

2: bis-triphenylphosphine-palladium(II) chloride; copper(II) oxide / N,N-dimethyl-formamide / 110 °C

3: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tert-butyl alcohol; acetonitrile; water

With bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; n-butyllithium; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; N,N',N'-trimethylenediamine; copper(II) oxide; In tetrahydrofuran; hexane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2013.06.028

Reference yield:

(2-formyl-6-methoxy3-pyridyl)tributylstannane (239463-13-9) → 3-[4-(1(S)-t-butyldimethylsilyloxymethyl-2,2-dimethylpropylcarbamoyl)-2-benzyloxycarbonylphenyl]-6-methoxy-2-pyridinecarboxylic acid (431048-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(II) oxide / N,N-dimethyl-formamide / 110 °C

2: sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene / tert-butyl alcohol; acetonitrile; water

With bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; copper(II) oxide; In water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2013.06.028

upstream raw materials:

6-methoxypyridine-2-carbaldehyde

(2-formyl-6-methoxy3-pyridyl)tributylstannane

2-hydroxy-5-formylbenzoic acid

benzyl 2-hydroxy-5-formylbenzoate

Downstream raw materials:

C₄₃H₄₃N₅O₈

C₄₉H₅₇N₅O₈Si