5-Formylsalicylic acid

Base Information

Chemical Name:5-Formylsalicylic acid
CAS No.:616-76-2
Molecular Formula:C8H6O4
Molecular Weight:166.133
Hs Code.:29189900
European Community (EC) Number:210-492-0
NSC Number:16527,15046
UNII:23V3W745T8
DSSTox Substance ID:DTXSID60210608
Nikkaji Number:J62.828J
Wikidata:Q72479460
ChEMBL ID:CHEMBL229240
Mol file:616-76-2.mol

Synonyms:3-formylsalicylic acid;5-formylsalicylic acid

Suppliers and Price of 5-Formylsalicylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
5-Formylsalicylic Acid >98.0%(HPLC)(T)
5g
$ 27.00

TCI Chemical
5-Formylsalicylic Acid >98.0%(HPLC)(T)
25g
$ 83.00

SynQuest Laboratories
5-FORMYLSALICYLIC ACID 95%
5 g
$ 45.00

SynQuest Laboratories
5-FORMYLSALICYLIC ACID 95%
25 g
$ 105.00

Sigma-Aldrich
5-Formylsalicylic acid 95%
5g
$ 189.00

Matrix Scientific
5-Formyl-2-hydroxybenzoic acid
500mg
$ 10.00

Matrix Scientific
5-Formyl-2-hydroxybenzoic acid
5g
$ 19.00

Matrix Scientific
5-Formyl-2-hydroxybenzoic acid
1g
$ 12.00

Crysdot
5-Formyl-2-hydroxybenzoicacid 95+%
1000g
$ 731.00

Crysdot
5-Formyl-2-hydroxybenzoicacid 95+%
500g
$ 406.00

Total 91 raw suppliers

Chemical Property of 5-Formylsalicylic acid

Chemical Property:

Appearance/Colour:light beige fine crystalline powder
Vapor Pressure:7.53E-06mmHg at 25°C
Melting Point:250 °C (dec.)(lit.)
Refractive Index:1.4611 (estimate)
Boiling Point:361.2 °C at 760 mmHg
PKA:2.67±0.10(Predicted)
Flash Point:186.5 °C
PSA：74.60000
Density:1.482 g/cm³
LogP:0.90290
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:166.02660867
Heavy Atom Count:12
Complexity:190

Purity/Quality:

99% ^*data from raw suppliers

5-Formylsalicylic Acid >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C=O)C(=O)O)O
Uses 5-Formylsalicylic Acid is used as a selective phase for the extraction of iron(III) in silica gel. It is also used in preparation of styrylquinolines as potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.

Technology Process of 5-Formylsalicylic acid

There total 20 articles about 5-Formylsalicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 89-56-5
5-Methylsalicylic acid

: 616-76-2
2-hydroxy-5-formylbenzoic acid

Guidance literature:: With oxygen; cobalt(II) diacetate tetrahydrate; sodium hydroxide; In ethylene glycol; at 80 ℃; for 8h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2013.12.077

Reference yield: 73.0%

: 619-21-6
m-formylphenyl benzoic acid

: 616-76-2
2-hydroxy-5-formylbenzoic acid

Guidance literature:: With oxygen; potassium acetate; palladium diacetate; C₁₉H₂₄N₂O; p-benzoquinone; In N,N-dimethyl-formamide; at 110 ℃; for 24h; under 760.051 Torr; regioselective reaction;
DOI:10.1126/science.abg2362

Reference yield: 55.7%

: 100-97-0
hexamethylenetetramine

: 69-72-7,25496-36-0,8052-31-1
salicylic acid

: 610-04-8
3-formylsalicylic acid

: 616-76-2
2-hydroxy-5-formylbenzoic acid

Guidance literature:: hexamethylenetetramine; salicylic acid; With copper(I) oxide; In trifluoroacetic acid; for 5h; Reflux;

With hydrogenchloride; In water; at 20 ℃; for 1h; Concentration; Reagent/catalyst; regioselective reaction;
DOI:10.1007/s11164-014-1881-5