2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Name:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine
CAS No.:1332875-95-2
Molecular Formula:C₂₀H₁₉Cl₂N₅
Molecular Weight:400.31
Hs Code.:

Synonyms:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Property of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

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Technology Process of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

There total 7 articles about 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-97-4
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

: 1332875-95-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: With iron; acetic acid; at 100 ℃; for 3h;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-95-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: tetrahydrofuran / 0.25 h / 20 °C

6.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

7.1: iron / acetic acid / 3 h / 100 °C

With sulfuryl dichloride; oxalyl dichloride; water; iron; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 6.1: Suzuki Coupling;

Reference yield:

: 685513-51-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid

: 1332875-95-2
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2-chloro-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: tetrahydrofuran / 0.25 h / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

4: iron / acetic acid / 3 h / 100 °C

With oxalyl dichloride; iron; caesium carbonate; N,N-dimethyl-formamide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki Coupling;