5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

Base Information

Chemical Name:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide
CAS No.:1332875-97-4
Molecular Formula:C₂₀H₁₉Cl₂N₅O₃
Molecular Weight:448.309
Hs Code.:

Synonyms:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

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Chemical Property of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

There total 6 articles about 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-96-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (6-bromo-3-nitro-pyridin-2-yl)-amide

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1332875-97-4
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-97-4
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: tetrahydrofuran / 0.25 h / 20 °C

6.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

With sulfuryl dichloride; oxalyl dichloride; water; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 6.1: Suzuki Coupling;

Reference yield:

: 685513-51-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid

: 1332875-97-4
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-3-nitro-pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: tetrahydrofuran / 0.25 h / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

With oxalyl dichloride; caesium carbonate; N,N-dimethyl-formamide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki Coupling;