4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:1401225-88-4
Molecular Formula:C₂₃H₁₆F₃N₃O₃S
Molecular Weight:471.46
Hs Code.:

Synonyms:4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 1 articles about 4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1401225-59-9
4-benzyloxymethyl-4-(thiophen-3-yl)imidazolidine-2,5-dione

: 1401225-88-4
4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: With copper(I) oxide; In N,N-dimethyl acetamide; at 135 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield: 93.0%

: 1401225-88-4
4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 74-88-4
methyl iodide

: 1401225-99-7
4-[3-methyl-4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield:

: 1401225-88-4
4-[4-benzyloxymethyl-2,5-dioxo-4-(thiophen-3-yl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 1401226-20-7
4-(4-hydroxymethyl-3-methyl-2,5-dioxo-4-thiophen-3-yl-imidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon / ethanol; cyclohexene / 3 h / 80 °C / Sealed tube; Inert atmosphere

With 10 wt% Pd(OH)2 on carbon; potassium carbonate; In ethanol; N,N-dimethyl-formamide; cyclohexene;
DOI:10.1021/jm300281x