8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Base Information

Chemical Name:8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole
CAS No.:1346262-90-5
Molecular Formula:C₂₆H₂₁N₃O₂
Molecular Weight:407.472
Hs Code.:

Synonyms:8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

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Chemical Property of 8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

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Technology Process of 8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

There total 6 articles about 8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1346262-73-4
C₁₈H₁₄N₂O

: 13820-14-9
4-methylbenzonitrile oxide

: 1346262-90-5
8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: C₁₈H₁₄N₂O; With triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; at 0 - 5 ℃; for 0.166667h; Inert atmosphere;

4-methylbenzonitrile oxide; In dichloromethane; at 0 - 20 ℃; for 0.666667h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c1ob06072d

Reference yield:

: 3235-02-7,3717-15-5,3717-16-6,140461-26-3,140461-27-4
p-methylbenzaldehyde oxime

: 1346262-90-5
8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / dichloromethane / 0.03 h / 0 - 5 °C

3.1: triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

3.2: 0.67 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06072d

Reference yield:

: C₁₅H₁₂N₂O

: 1346262-90-5
8-methoxy-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 4 h / Reflux

2.1: triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

2.2: 0.67 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06072d