(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

Base Information

Chemical Name:(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride
CAS No.:1415481-68-3
Molecular Formula:C₁₄H₂₀ClNO₃*ClH
Molecular Weight:322.232
Hs Code.:

Synonyms:(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

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Chemical Property of (2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

There total 6 articles about (2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415312-30-9
(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester

: 71-36-3
butan-1-ol

: 1415481-68-3
(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

Guidance literature:: With hydrogenchloride; at 70 ℃; for 24h;

Reference yield:

: 1415312-26-3
[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

: 1415481-68-3
(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / Reflux

1.2: 4 h / Reflux

2.1: hydrogenchloride / 24 h / 70 °C

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1270301-63-7
C₁₇H₁₆ClNO₄

: 1415481-68-3
(2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

3.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

4.1: hydrogenchloride / 1,4-dioxane / Reflux

4.2: 4 h / Reflux

5.1: hydrogenchloride / 24 h / 70 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;