(1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid

Base Information

• Chemical Name: (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid
• CAS No.: 120881-34-7
• Molecular Formula: C₂₂H₂₇NO₅
• Molecular Weight: 385.46
• Mol file: 120881-34-7.mol

Synonyms:(1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid

Chemical Property of (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid

There total 3 articles about (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1R,5S,7R)-1,5,7-Trimethyl-2,4-dioxo-3-oxa-bicyclo[3.3.1]nonane-7-carboxylic acid (1-benzyl-2-oxo-propyl)-amide (120881-32-5) → (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (120881-34-7)

Guidance literature:

With pyridine; for 2h; Heating;

DOI:10.1021/ja00006a050

Reference yield:

3-amino-4-phenyl-2-butanone hydrochloride (5440-27-7) → (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (120881-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: pyridine / Heating

With triethylamine; In pyridine;

DOI:10.1021/ja00194a058

Reference yield:

5-(chloroformyl)-cis,cis-1,3,5-trimethylcyclohexane-1,3-dicarboxylic anhydride (79410-29-0) → (1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (120881-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: pyridine / Heating

With triethylamine; In pyridine;

DOI:10.1021/ja00194a058

upstream raw materials:

(1R,5S,7R)-1,5,7-Trimethyl-2,4-dioxo-3-oxa-bicyclo[3.3.1]nonane-7-carboxylic acid (1-benzyl-2-oxo-propyl)-amide

5-(chloroformyl)-cis,cis-1,3,5-trimethylcyclohexane-1,3-dicarboxylic anhydride

3-amino-4-phenyl-2-butanone hydrochloride

Downstream raw materials:

(1S,5R,7S)-3-(1-Benzyl-2-oxo-propyl)-1,5,7-trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid methyl ester