tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

Base Information

Chemical Name:tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate
CAS No.:348624-11-3
Molecular Formula:C₂₄H₃₅N₃O₃
Molecular Weight:413.56
Hs Code.:

Synonyms:tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

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Technology Process of tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

There total 1 articles about tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349095-03-0
tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate

: 348624-11-3
tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

Guidance literature:: In xylene; at 130 ℃; for 4.5h;
DOI:10.1021/jm061010z

Reference yield:

: 348624-11-3
tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

: 348624-12-4
(3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 46h;
DOI:10.1021/jm061010z

Reference yield:

: 348624-11-3
tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

: (3R)-6-Cyclohexyl-N-hydroxy-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 418 mg / HCl / dioxane / 46 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 1 h

2.2: O-trimethylsilyl hydroxylamine / CH₂Cl₂ / 18 h

2.3: 128 mg / MeOH / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; 1,1'-carbonyldiimidazole; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm061010z