tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate

Base Information

• Chemical Name: tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate
• CAS No.: 349095-03-0
• Molecular Formula: C₂₄H₃₇N₃O₄
• Molecular Weight: 431.575
• Mol file: 349095-03-0.mol

Synonyms:tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate

Chemical Property of tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate

There total 2 articles about tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1Z)-N'-hydroxy-2-(3-pyridinyl)ethanimidamide (261735-05-1,348624-10-2,137499-45-7) + (2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid (343251-07-0) → tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (349095-03-0)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm061010z

Reference yield:

3-pyridinylacetonitrile (6443-85-2) → tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (349095-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; Et₃N / methanol / 20 °C

2: 835 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N-methylmorpholine; 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 18 h / 20 °C

With 4-methyl-morpholine; hydroxylamine hydrochloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm061010z

Reference yield:

tert-butyl (3R)-3-[({[(Z)-1-amino-2-(3-pyridinyl)ethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (349095-03-0) → tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate (348624-11-3)

Guidance literature:

In xylene; at 130 ℃; for 4.5h;

DOI:10.1021/jm061010z

upstream raw materials:

(1Z)-N'-hydroxy-2-(3-pyridinyl)ethanimidamide

(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

3-pyridinylacetonitrile

Downstream raw materials:

tert-butyl (3R)-6-cyclohexyl-3-[3-(3-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate