(S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol

Base Information

• Chemical Name: (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol
• CAS No.: 216306-29-5
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.311
• Mol file: 216306-29-5.mol

Synonyms:(S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol

Chemical Property of (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol

There total 1 articles about (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-phenylpropenal (14371-10-9) + (S)-valinol (2026-48-4,473-75-6) → (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol (216306-29-5)

Guidance literature:

In diethyl ether; for 1.33333h; Ambient temperature;

DOI:10.1055/s-1998-1880

Reference yield: 70.0%

allyl bromide (106-95-6) + (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol (216306-29-5) → (2S)-3-methyl-2-[(1S)-1-(4-styrylphenyl)but-3-enylamino]butan-1-ol (216306-34-2)

Guidance literature:

(S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol; samarium; trimethylaluminum; In hexane; at 0 ℃;

allyl bromide; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages.;

DOI:10.1021/jo0014616

Reference yield:

allyl bromide (106-95-6) + (S)-3-Methyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-butan-1-ol (216306-29-5) → (S)-3-Methyl-2-[(R)-1-((E)-styryl)-but-3-enylamino]-butan-1-ol + (2S)-3-methyl-2-[(1S)-1-(4-styrylphenyl)but-3-enylamino]butan-1-ol (216306-34-2)

Guidance literature:

With iodine; magnesium; Yield given. Multistep reaction. Yields of byproduct given; 1.) Et₂O, 2.) Et₂O, reflux, 2 h;

DOI:10.1055/s-1998-1880

upstream raw materials:

(E)-3-phenylpropenal

(S)-valinol

Downstream raw materials:

(2S)-3-methyl-2-[(1S)-1-(4-styrylphenyl)but-3-enylamino]butan-1-ol