N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

Base Information

Chemical Name:N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide
CAS No.:1100767-61-0
Molecular Formula:C₂₂H₂₅F₃N₄O₄
Molecular Weight:466.46
Hs Code.:

Synonyms:N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

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Chemical Property of N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

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Technology Process of N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

There total 6 articles about N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1100767-60-9
1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethylamine triflouroacetate

: 1100767-27-8
N-(4-carbamimidoyl-phenyl)-malonamic acid trifluoroacetate

: 1100767-61-0
N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100767-61-0
N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 20 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

2.2: 4 h / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium 10% on activated carbon; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1100767-24-5
N-[4-(N-hydroxycarbamimidoyl)-phenyl]-malonamic acid ethyl ester

: 1100767-61-0
N-(4-carbamimidoyl-phenyl)-N'-{1-[4-(2-methoxy-ethoxy)-3-trifluoromethyl-phenyl]-ethyl}-malonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

1.2: 4 h / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; ammonium formate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium 10% on activated carbon; In acetic acid; N,N-dimethyl-formamide;