(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

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Chemical Name:(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate
CAS No.:1344708-49-1
Molecular Formula:C₂₇H₂₅F₃N₄O₆
Molecular Weight:558.514
Hs Code.:

Synonyms:(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

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Chemical Property of (R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

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Technology Process of (R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

There total 10 articles about (R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.7%

: 1344708-41-3,1344708-42-4,1344708-43-5
(R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 1344708-49-1
(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344708-49-1
(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3: Jones reagent / acetone / 20 °C

4: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile

6: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344708-49-1
(R/S)-tert-butyl 3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2: Jones reagent / acetone / 20 °C

3: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile

5: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;