(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

Base Information

Chemical Name:(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride
CAS No.:248923-10-6
Molecular Formula:C₂₃H₃₁F₂N₃*ClH
Molecular Weight:423.977
Hs Code.:

Synonyms:(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

Chemical Property:

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Technology Process of (S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

There total 4 articles about (S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 248921-97-3
(S)-(1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-carbamic acid tert-butyl ester

: 248923-10-6
(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 248923-09-3
(S)-tert-butyl (1-(methoxyamino)-4-methyl-1-oxopentan-2-yl)carbamate

: 248923-10-6
(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: NaHSO₄ / water

2: hydrogenchloride; sodium cyanoborohydride / methanol; acetic acid; ethyl acetate

3: trifluoroacetic acid / dichloromethane

With hydrogenchloride; NaHSO₄; sodium cyanoborohydride; trifluoroacetic acid; In methanol; dichloromethane; water; acetic acid; ethyl acetate;

Reference yield:

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 248923-10-6
(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium cyanoborohydride / methanol; acetic acid; ethyl acetate

2: trifluoroacetic acid / dichloromethane

With hydrogenchloride; sodium cyanoborohydride; trifluoroacetic acid; In methanol; dichloromethane; acetic acid; ethyl acetate;