(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

Base Information

Chemical Name:(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide
CAS No.:248921-98-4
Molecular Formula:C₃₀H₄₂F₂N₄O
Molecular Weight:512.686
Hs Code.:

Synonyms:(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

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Chemical Property of (S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

There total 5 articles about (S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27817-35-2
azepane-1-carbonyl chloride

: 248923-10-6
(S)-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butylamine monohydrochloride

: 248921-98-4
(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In ethyl acetate; benzene;

Reference yield:

: 248923-09-3
(S)-tert-butyl (1-(methoxyamino)-4-methyl-1-oxopentan-2-yl)carbamate

: 248921-98-4
(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: NaHSO₄ / water

2: hydrogenchloride; sodium cyanoborohydride / methanol; acetic acid; ethyl acetate

3: trifluoroacetic acid / dichloromethane

4: dmap; N-ethyl-N,N-diisopropylamine / ethyl acetate; benzene

With hydrogenchloride; dmap; NaHSO₄; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;

Reference yield:

: 248921-97-3
(S)-(1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-carbamic acid tert-butyl ester

: 248921-98-4
(S)-Azepane-1-carboxylic acid (1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-3-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: dmap; N-ethyl-N,N-diisopropylamine / ethyl acetate; benzene

With dmap; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; benzene;