Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

Base Information

Chemical Name:Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide
CAS No.:86662-07-9
Molecular Formula:C₂₁H₂₆BrN₃O₄S₂
Molecular Weight:528.491
Hs Code.:

Synonyms:Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

Suppliers and Price of Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

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Technology Process of Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

There total 4 articles about Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-91-8,99108-56-2
morpholine

: 86662-11-5
N-(2-bromoethyl)-2'-isothiocyanato-4'-methoxytosylanilide

: 86662-07-9
Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

Guidance literature:: In diethyl ether; for 3h; Heating;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 3360-81-4
N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

: 86662-07-9
Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / dimethylformamide / on steam bath

2: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

3: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 93 percent / diethyl ether / 3 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 16058-88-1
N-(2-Bromoethyl)-N-tosyl-4-methoxy-2-nitraniline

: 86662-07-9
Morpholine-4-carbothioic acid {2-[(2-bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

2: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 93 percent / diethyl ether / 3 h / Heating

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4020(01)91886-1