N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide
• CAS No.: 3360-81-4
• Molecular Formula: C14H14N2O5S
• Molecular Weight: 322.342
• Hs Code.: 2935009090
• Mol file: 3360-81-4.mol

Synonyms:HMS2749J18;2-(4-methylbenzenesulfonylamino)-5-methoxynitrobenzene;toluene-4-sulfonic acid-(4-methoxy-2-nitro-anilide);N-(4-methoxy-2-nitro-phenyl)-toluene-4-sulfonamide;2<<(4-methylphenyl)sulfonyl>amino>-5-methoxynitrobenzene;4'-methoxy-2'-nitro-p-toluenesulfonanilide;

Chemical Property of N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 4.53E-10mmHg at 25°C
• Boiling Point: 498.4°Cat760mmHg
• Flash Point: 255.3°C
• PSA: 109.60000
• Density: 1.397g/cm³
• LogP: 4.38960

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

There total 8 articles about N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-toluenesulfonyl chloride (98-59-9) + 4-methoxy-2-nitroaniline (96-96-8) → N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide (3360-81-4)

Guidance literature:

With triethylamine; In dichloromethane; at 4 ℃;

DOI:10.1002/adsc.201800824

Reference yield: 91.0%

N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide (1150-26-1) → N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide (3360-81-4)

Guidance literature:

With tert.-butylnitrite; In acetonitrile; at 45 ℃; for 2.5h; chemoselective reaction;

DOI:10.1039/c2cc37481a

Reference yield:

4-methoxy-aniline (104-94-9) → N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide (3360-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol; sodium acetate

2: glacial acetic acid; nitric acid / 10 - 22 °C

With ethanol; nitric acid; sodium acetate; acetic acid;

upstream raw materials:

N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide

p-toluenesulfonyl chloride

4-methoxy-2-nitroaniline

nitric acid

Downstream raw materials:

toluene-4-sulfonic acid-[N-(3-diethylamino-propyl)-4-methoxy-2-nitro-anilide]

toluene-4-sulfonic acid-(4-methoxy-2-nitro-N-propyl-anilide)

4-methoxy-2-nitroaniline

toluene-4-sulfonic acid-[N-(2-diethylamino-ethyl)-4-methoxy-2-nitro-anilide]